He trained in Sydney, and emigrated to the United States in 1900. After a trip in 1910 to San Francisco, he decided to settle in New York where he was excited about the rhythms of city life. In 1915, largely self taught, he made his first etching and also pursued drypoint. From 1920 to 1922, he lived in Japan, and that experience influenced his work. In 1934, he and lithographer George Miller organized a printmaking school in New York, and Lewis taught at the Art Students League from 1944 to 1951.
Images of New York City fill his prints that show industry, commerce, and immigrant life. Like artist Edward Hoppper, Lewis especially liked night scenes, which offered him the chance to show light and shadow. He continued scenes from his print studies of moody urban streets and structures with and without dominating figures. In October, 1998, his Cityscapes on Paper was shown at the Brooklyn Museum.

